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KMID : 0378019670100030078
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New Medical Journal
1967 Volume.10 No. 3 p.78 ~ p.80
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The Minimal Inhibitory Concentrations of Ethionamide and Cycloserine to the Tubercle Bacil
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宋浩星/Song, Ho Sung
洪永杓/鄭寅聖/趙載承/Hong, Young Pyo/Jung, In Sung/Cho, Jae Sung
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Abstract
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The minimal .inhibitory concentrations of ethionamide and cycloserine to. H37Rv strain and wild strains in Youman´s media are increasing stepwise as the incubation time pass. One of the causes of this phenomenon might be owing- to the progressive decrease of effective -drug con centrations contained in. the media. The minimal inhibitory concentrations of ethionamide and cycloserine in H37Rv strain are 0.8 mcg/ml and 6 mcg/ml respectively. In wild strains, the minimal inhibitory concentrations of ethionamide are ranged from 0.4mcg/ml to 2.0mcg/ml in 85 strains, and that of cyclose rine are from below 5mcg/ml to 10mcg/ml in 1Q strains by Youman´s media at 10th incubation day. On 4th incubation day microscopy is done the evidence of growing of cells are judged by cord formed and incre ased-tubercle bacilli when inocula are made with vidually seperated cells. As comparing with the turbidityl on 10th day, above mentioned microscopic findings an identical the early detection of resistance to these two drugs seems feasible and practicable.
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KEYWORD
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